RAF Typhoon FGR4s have operated alongside France's air force in a joint strike targeting an hidden munitions depot in Syrian territory operated by the IS group, as stated by the British defence ministry.
The site, located using reconnaissance, was assessed as housing weapons and explosive materials, the statement said, and was situated in hills just above Palmyra in the heart of Syria.
"The RAF jets utilized precision-guided Paveway IV munitions to target a several entry passages leading to the facility... preliminary assessments suggest the target was engaged successfully," the ministry announced.
There was no indication of any harm to civilians in the operation on Saturday evening and each participating jet returned to base without incident, the MoD added.
The Typhoon fighters were assisted by a Voyager aerial refuelling aircraft.
The Islamic State group - referred to as Daesh - imposed jihadist rule over parts of Syria and Iraq prior to its 2019 collapse.
"This action underscores the UK's leading role, and determination to operate in unison with allied nations, to eliminate any revival of Daesh and their harmful and extremist ideologies in the area," Britain's Defence Chief John Healey said.
RAF aircraft have carried out patrols over Syrian airspace to "prevent any attempted resurgence" of the group after its defeat at the climactic battle in Baghuz in the year 2019, the MoD reported.
"I want to thank all the members of the UK armed forces participating in this mission for their professionalism and their courage," the Defence Secretary added. "Including them were thousands of UK service members deployed over Christmas and New Year. This operation, to take out terrorist threats who pose a risk to our security, demonstrates how British military are always on standby, throughout the year, ensuring Britain's security domestically and strong abroad."
During December, the US military conducted what it termed a "major assault" targeting Daesh sites in the country, after an assault killed two US troops and a civilian interpreter in the Palmyra area.
The U.N. estimates IS still maintains roughly 5-7 thousand combatants in Iraq and Syria.
